Yogiraj Centre for Dermatology & Cosmetology (YCDC) has an active research forum with a dynamic team focusing on clinical research, teaching and extension activities. Each of our doctors is actively engaged in research and advancement in their individual fields. Our effort is to develop and refine advanced testing, treatment and techniques in dermatology.
DESCRIPTIVE STUDY OF ALOPECIA PATTERNS AND THEIR RELATION TO THYROID DYSFUNCTION AND ASSOCIATED SKIN CONDITIONS – BY DR. MAYA VINCENT
Here we have attempted to study multiple variables of Alopecia with relation to thyroid disorder. A total of 1232 patients were seen during a period of 25 months. Patients who attended our dermatology center with complaints of hair loss of any part of the body were seen and classified into different sex, age and patterns of alopecia based on clinical diagnosis and their relationship, thyroid disorder and associated clinical conditions was studied. They were tested for TSH and autoantibodies to thyroid peroxidase (TPOAb) were categorized into euthyroid, hypothyroid, hyperthyroid and subclinical according to lab results. A significant difference between sex and age thyroid dysfunction, patterns of alopecia and clinical skin conditions were seen.
MELANOCYTE NONCULTURED CELL SUSPENSION TRANSFER BY – DR. SUNIL MENON
This is the latest and the best technique cosmetically as well as graft take up wise where a thick cell suspension made up of the melanocytes is prepared from the donor skin specimen and transferred to the vitiligo site-repigmentation is usually seen within 1- 3 months and the surgery site is almost non distinguishable from the surrounding normal skin
Vitiligo Abdomen Suspension Transfer
40 Days after Melanocyte
The course of the disease is unpredictable, though most often it shows a tendency towards slow progression. Many lesions may remain static for an indefinite period or show some degree of spontaneous regression with development of pigment spots .Others may show repigmentation of some lesions, extensions of others and appearance of new lesions at other sites simultaneously. Vitiligo for long has been a disease with an enormous amount of social stigma and alienation associated with it. The limited treatment options available also did not help matters. But recently with the availability of newer enzyme preparations, narrow band UVB phototherapy and melanocyte transfer techniques vitiligo patients can now look forward for a faster cure.
THESIS TOPIC-SEROEPIDEMIOLOGICAL STUDY OF HSV-2 ANTIBODIES IN PATIENTS WITH STI – DR. KAVITHA K.
Serological evidence of herpes simplex virus type 2 infection was studied in 102 subjects who were screened in the STD clinic of Dermatology department of Medical College Hospital, Thiruvananthapuram. This group was constituted by 51 persons with clinical evidence of any of the sexually transmitted infections (STIs) and 51 persons from the general population who were taken as a comparison group. Of the 51 persons with STIs, 21 were clinically diagnosed as herpes genitalis, and the other 30 were having STIs other than herpes genitalis
The aims of the study were (a) to study the seroprevalence of HSV-2 antibodies among all patients with STIs.(b) to know whether there is any difference in serological titre between herpes genitalis patients, patients with other STIs,and general population.(c) to derive the prevalence of asymptomatic HSV-2 infection among patients with other STIs and general population.
- HSV-2antibody titres were positive in 95.2% patients with herpes genitalis. HSV-2 IgM was positive in 60% patients with HG and HSV-2 IgG was positive in 93.6% of recurrent herpes genitalispatients.The low IgM positivity in primary herpes genitalis cases may indicate a short duration of persistence of IgMtitre positivity in primary herpes genitalis cases.
- Both IgM and IgG positivity was found in 47.6% cases of HG whereas any of the IgG or IgM positivity was found in 95.2% cases of HG.
- 40% patients with first episode of HG did not show IgM positivity and 50% of these patients showed an IgGpositivity.This stresses the observation that a reasonably good number of patients with first episode of HG were in fact having non-primary first episode.
- High titre of HSV-2 antibody showed a positive correlation with frequency of recurrences indicating the role of serology in assessing the clinical activity in HG.
- HSV-2 seropositivity in patients with STIs was found to be 58.8% in this series, which conforms with the HSV seropositivity in all STI patients in most of the Indian studies.This strongly indicates the necessity for screening all STI patients for HSV-2 seropositivity.
- HSV-2 seropositivity (either IgM or IgG) was observed in 33.3% patients with other STIs and 27.5% patients of the general population studied.These two groups of patients in fact constitute patients with asymptomatic HSV-2 infection.This highlights the importance of looking for asymptomatic HSV-2 infection not only in vulnerable groups ,but also in the general population,from a public health point of view.
- Among patients with asymptomatic forms of syphilis (latent syphilis of unknown duration) 50% had HSV-2 antibody positivity.This also necessitates screening for HSV-2 antibody among all patients with syphilis.